PT  - JOURNAL ARTICLE
AU  - Bennett, Malcolm J.
AU  - Marchant, Alan
AU  - Green, Haydn G.
AU  - May, Sean T.
AU  - Ward, Sally P.
AU  - Millner, Paul A.
AU  - Walker, Amanda R.
AU  - Schulz, Burkhard
AU  - Feldmann, Kenneth A.
TI  - <strong><em>Arabidopsis AUX1</em></strong> Gene: A Permease-Like Regulator of Root Gravitropism
AID  - 10.1126/science.273.5277.948
DP  - 1996 Aug 16
TA  - Science
PG  - 948--950
VI  - 273
IP  - 5277
4099  - http://science.sciencemag.org/content/273/5277/948.short
4100  - http://science.sciencemag.org/content/273/5277/948.full
SO  - Science1996 Aug 16; 273
AB  - The plant hormone auxin regulates various developmental processes including root formation, vascular development, and gravitropism. Mutations within the AUX1 gene confer an auxin-resistant root growth phenotype and abolish root gravitropic curvature. Polypeptide sequence similarity to amino acid permeases suggests that AUX1 mediates the transport of an amino acid-like signaling molecule. Indole-3-acetic acid, the major form of auxin in higher plants, is structurally similar to tryptophan and is a likely substrate for the AUX1 gene product. The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature.