PT  - JOURNAL ARTICLE
AU  - Bergelson, Jeffrey M.
AU  - Cunningham, Jennifer A.
AU  - Droguett, Gustavo
AU  - Kurt-Jones, Evelyn A.
AU  - Krithivas, Anita
AU  - Hong, Jeong S.
AU  - Horwitz, Marshall S.
AU  - Crowell, Richard L.
AU  - Finberg, Robert W.
TI  - Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
AID  - 10.1126/science.275.5304.1320
DP  - 1997 Feb 28
TA  - Science
PG  - 1320--1323
VI  - 275
IP  - 5304
4099  - http://science.sciencemag.org/content/275/5304/1320.short
4100  - http://science.sciencemag.org/content/275/5304/1320.full
SO  - Science1997 Feb 28; 275
AB  - A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.