PT - JOURNAL ARTICLE AU - Bergelson, Jeffrey M. AU - Cunningham, Jennifer A. AU - Droguett, Gustavo AU - Kurt-Jones, Evelyn A. AU - Krithivas, Anita AU - Hong, Jeong S. AU - Horwitz, Marshall S. AU - Crowell, Richard L. AU - Finberg, Robert W. TI - Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 AID - 10.1126/science.275.5304.1320 DP - 1997 Feb 28 TA - Science PG - 1320--1323 VI - 275 IP - 5304 4099 - http://science.sciencemag.org/content/275/5304/1320.short 4100 - http://science.sciencemag.org/content/275/5304/1320.full SO - Science1997 Feb 28; 275 AB - A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.