RT Journal Article
SR Electronic
T1 Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
JF Science
JO Science
FD American Association for the Advancement of Science
SP 218
OP 220
DO 10.1126/science.275.5297.218
VO 275
IS 5297
A1 Jang, Meishiang
A1 Cai, Lining
A1 Udeani, George O.
A1 Slowing, Karla V.
A1 Thomas, Cathy F.
A1 Beecher, Christopher W. W.
A1 Fong, Harry H. S.
A1 Farnsworth, Norman R.
A1 Kinghorn, A. Douglas
A1 Mehta, Rajendra G.
A1 Moon, Richard C.
A1 Pezzuto, John M.
YR 1997
UL http://science.sciencemag.org/content/275/5297/218.abstract
AB Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.