RT Journal Article SR Electronic T1 Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations JF Science JO Science FD American Association for the Advancement of Science SP 117 OP 120 DO 10.1126/science.278.5335.117 VO 278 IS 5335 A1 Tamura, Yasuaki A1 Peng, Ping A1 Liu, Kang A1 Daou, Maria A1 Srivastava, Pramod K. YR 1997 UL http://science.sciencemag.org/content/278/5335/117.abstract AB Immunotherapy of mice with preexisting cancers with heat shock protein preparations derived from autologous cancer resulted in retarded progression of the primary cancer, a reduced metastatic load, and prolongation of life-span. Treatment with heat shock protein preparations derived from cancers other than the autologous cancer did not provide significant protection. Spontaneous cancers (lung cancer and melanoma), chemically induced cancers (fibrosarcoma and colon carcinoma), and an ultraviolet radiation-induced spindle cell carcinoma were tested, and the results support the efficacy of autologous cancer–derived heat shock protein–peptide complexes in immunotherapy of cancers without the need to identify specific tumor antigenic epitopes.