RT Journal Article
SR Electronic
T1 Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations
JF Science
JO Science
FD American Association for the Advancement of Science
SP 117
OP 120
DO 10.1126/science.278.5335.117
VO 278
IS 5335
A1 Tamura, Yasuaki
A1 Peng, Ping
A1 Liu, Kang
A1 Daou, Maria
A1 Srivastava, Pramod K.
YR 1997
UL http://science.sciencemag.org/content/278/5335/117.abstract
AB Immunotherapy of mice with preexisting cancers with heat shock protein preparations derived from autologous cancer resulted in retarded progression of the primary cancer, a reduced metastatic load, and prolongation of life-span. Treatment with heat shock protein preparations derived from cancers other than the autologous cancer did not provide significant protection. Spontaneous cancers (lung cancer and melanoma), chemically induced cancers (fibrosarcoma and colon carcinoma), and an ultraviolet radiation-induced spindle cell carcinoma were tested, and the results support the efficacy of autologous cancer–derived heat shock protein–peptide complexes in immunotherapy of cancers without the need to identify specific tumor antigenic epitopes.