PT - JOURNAL ARTICLE AU - Krȩz˙el, Wojciech AU - Ghyselinck, Norbert AU - Samad, Tarek A. AU - Dupé, Valérie AU - Kastner, Philippe AU - Borrelli, Emiliana AU - Chambon, Pierre TI - Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice AID - 10.1126/science.279.5352.863 DP - 1998 Feb 06 TA - Science PG - 863--867 VI - 279 IP - 5352 4099 - http://science.sciencemag.org/content/279/5352/863.short 4100 - http://science.sciencemag.org/content/279/5352/863.full SO - Science1998 Feb 06; 279 AB - In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor β and retinoid X receptors β and γ resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.