PT  - JOURNAL ARTICLE
AU  - Krȩz˙el, Wojciech
AU  - Ghyselinck, Norbert
AU  - Samad, Tarek A.
AU  - Dupé, Valérie
AU  - Kastner, Philippe
AU  - Borrelli, Emiliana
AU  - Chambon, Pierre
TI  - Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice
AID  - 10.1126/science.279.5352.863
DP  - 1998 Feb 06
TA  - Science
PG  - 863--867
VI  - 279
IP  - 5352
4099  - http://science.sciencemag.org/content/279/5352/863.short
4100  - http://science.sciencemag.org/content/279/5352/863.full
SO  - Science1998 Feb 06; 279
AB  - In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor β and retinoid X receptors β and γ resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.