RT Journal Article
SR Electronic
T1 Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1455
OP 1457
DO 10.1126/science.280.5368.1455
VO 280
IS 5368
A1 Brunet, Lisa J.
A1 McMahon, Jill A.
A1 McMahon, Andrew P.
A1 Harland, Richard M.
YR 1998
UL http://science.sciencemag.org/content/280/5368/1455.abstract
AB Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs. In mice lacking Noggin, cartilage condensations initiated normally but developed hyperplasia, and initiation of joint development failed as measured by the expression of growth and differentiation factor–5. The maturation of cartilage and Hoxd expression were unaffected. Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues.