PT  - JOURNAL ARTICLE
AU  - Thornberry, Nancy A.
AU  - Lazebnik, Yuri
TI  - Caspases: Enemies Within
AID  - 10.1126/science.281.5381.1312
DP  - 1998 Aug 28
TA  - Science
PG  - 1312--1316
VI  - 281
IP  - 5381
4099  - http://science.sciencemag.org/content/281/5381/1312.short
4100  - http://science.sciencemag.org/content/281/5381/1312.full
SO  - Science1998 Aug 28; 281
AB  - REVIEWApoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.