RT Journal Article
SR Electronic
T1 Caspases: Enemies Within
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1312
OP 1316
DO 10.1126/science.281.5381.1312
VO 281
IS 5381
A1 Thornberry, Nancy A.
A1 Lazebnik, Yuri
YR 1998
UL http://science.sciencemag.org/content/281/5381/1312.abstract
AB REVIEWApoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.