RT Journal Article
SR Electronic
T1 Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB<sub>1</sub> Receptor Knockout Mice
JF Science
JO Science
FD American Association for the Advancement of Science
SP 401
OP 404
DO 10.1126/science.283.5400.401
VO 283
IS 5400
A1 Ledent, Catherine
A1 Valverde, Olga
A1 Cossu, Gregorio
A1 Petitet, François
A1 Aubert, Jean-François
A1 Beslot, Françoise
A1 Böhme, Georg A.
A1 Imperato, Assunta
A1 Pedrazzini, Thierry
A1 Roques, Bernard P.
A1 Vassart, Gilbert
A1 Fratta, Walter
A1 Parmentier, Marc
YR 1999
UL http://science.sciencemag.org/content/283/5400/401.abstract
AB The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs, demonstrating the exclusive role of the CB1 receptor in mediating analgesia, reinforcement, hypothermia, hypolocomotion, and hypotension. The acute effects of opiates were unaffected, but the reinforcing properties of morphine and the severity of the withdrawal syndrome were strongly reduced. These observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.