RT Journal Article
SR Electronic
T1 Identification of a Nuclear Receptor for Bile Acids
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1362
OP 1365
DO 10.1126/science.284.5418.1362
VO 284
IS 5418
A1 Makishima, Makoto
A1 Okamoto, Arthur Y.
A1 Repa, Joyce J.
A1 Tu, Hua
A1 Learned, R. Marc
A1 Luk, Alvin
A1 Hull, Mitchell V.
A1 Lustig, Kevin D.
A1 Mangelsdorf, David J.
A1 Shan, Bei
YR 1999
UL http://science.sciencemag.org/content/284/5418/1362.abstract
AB Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7α-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid–binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.