PT - JOURNAL ARTICLE AU - Galitski, Timothy AU - Saldanha, Alok J. AU - Styles, Cora A. AU - Lander, Eric S. AU - Fink, Gerald R. TI - Ploidy Regulation of Gene Expression AID - 10.1126/science.285.5425.251 DP - 1999 Jul 09 TA - Science PG - 251--254 VI - 285 IP - 5425 4099 - http://science.sciencemag.org/content/285/5425/251.short 4100 - http://science.sciencemag.org/content/285/5425/251.full SO - Science1999 Jul 09; 285 AB - Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiaestrains that varied in ploidy from haploid to tetraploid. These genes were induced or repressed in proportion to the number of chromosome sets, regardless of the mating type. Ploidy-dependent repression of some G1 cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression. Moreover, ploidy regulation of the FLO11 gene had direct consequences for yeast development.