PT  - JOURNAL ARTICLE
AU  - Galitski, Timothy
AU  - Saldanha, Alok J.
AU  - Styles, Cora A.
AU  - Lander, Eric S.
AU  - Fink, Gerald R.
TI  - Ploidy Regulation of Gene Expression
AID  - 10.1126/science.285.5425.251
DP  - 1999 Jul 09
TA  - Science
PG  - 251--254
VI  - 285
IP  - 5425
4099  - http://science.sciencemag.org/content/285/5425/251.short
4100  - http://science.sciencemag.org/content/285/5425/251.full
SO  - Science1999 Jul 09; 285
AB  - Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiaestrains that varied in ploidy from haploid to tetraploid. These genes were induced or repressed in proportion to the number of chromosome sets, regardless of the mating type. Ploidy-dependent repression of some G1 cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression. Moreover, ploidy regulation of the FLO11 gene had direct consequences for yeast development.