PT  - JOURNAL ARTICLE
AU  - Miralles, Rosario
AU  - Gerrish, Philip J.
AU  - Moya, Andrés
AU  - Elena, Santiago F.
TI  - Clonal Interference and the Evolution of RNA Viruses
AID  - 10.1126/science.285.5434.1745
DP  - 1999 Sep 10
TA  - Science
PG  - 1745--1747
VI  - 285
IP  - 5434
4099  - http://science.sciencemag.org/content/285/5434/1745.short
4100  - http://science.sciencemag.org/content/285/5434/1745.full
SO  - Science1999 Sep 10; 285
AB  - In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.