RT Journal Article
SR Electronic
T1 Clonal Interference and the Evolution of RNA Viruses
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1745
OP 1747
DO 10.1126/science.285.5434.1745
VO 285
IS 5434
A1 Miralles, Rosario
A1 Gerrish, Philip J.
A1 Moya, Andrés
A1 Elena, Santiago F.
YR 1999
UL http://science.sciencemag.org/content/285/5434/1745.abstract
AB In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.