PT  - JOURNAL ARTICLE
AU  - Bouillet, Philippe
AU  - Metcalf, Donald
AU  - Huang, David C. S.
AU  - Tarlinton, David M.
AU  - Kay, Tom W. H.
AU  - Köntgen, Frank
AU  - Adams, Jerry M.
AU  - Strasser, Andreas
TI  - Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity
AID  - 10.1126/science.286.5445.1735
DP  - 1999 Nov 26
TA  - Science
PG  - 1735--1738
VI  - 286
IP  - 5445
4099  - http://science.sciencemag.org/content/286/5445/1735.short
4100  - http://science.sciencemag.org/content/286/5445/1735.full
SO  - Science1999 Nov 26; 286
AB  - Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim. Lymphoid and myeloid cells accumulated, T cell development was perturbed, and most older mice accumulated plasma cells and succumbed to autoimmune kidney disease. Lymphocytes were refractory to apoptotic stimuli such as cytokine deprivation, calcium ion flux, and microtubule perturbation but not to others. Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins.