RT Journal Article
SR Electronic
T1 A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination
JF Science
JO Science
FD American Association for the Advancement of Science
SP 495
OP 498
DO 10.1126/science.287.5452.495
VO 287
IS 5452
A1 McMurry, Michelle Taylor
A1 Krangel, Michael S.
YR 2000
UL http://science.sciencemag.org/content/287/5452/495.abstract
AB V(D)J recombination is developmentally regulated in vivo by enhancer-dependent changes in the accessibility of chromosomal recombination signal sequences to the recombinase, but the molecular nature of these changes is unknown. Here histone H3 acetylation was measured along versions of a transgenic V(D)J recombination reporter and the endogenous T cell receptor α/δ locus. Enhancer activity was shown to impart long-range, developmentally regulated changes in H3 acetylation, and H3 acetylation status was tightly linked to V(D)J recombination. H3 hyperacetylation is proposed as a molecular mechanism coupling enhancer activity to accessibility for V(D)J recombination.