RT Journal Article SR Electronic T1 A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination JF Science JO Science FD American Association for the Advancement of Science SP 495 OP 498 DO 10.1126/science.287.5452.495 VO 287 IS 5452 A1 McMurry, Michelle Taylor A1 Krangel, Michael S. YR 2000 UL http://science.sciencemag.org/content/287/5452/495.abstract AB V(D)J recombination is developmentally regulated in vivo by enhancer-dependent changes in the accessibility of chromosomal recombination signal sequences to the recombinase, but the molecular nature of these changes is unknown. Here histone H3 acetylation was measured along versions of a transgenic V(D)J recombination reporter and the endogenous T cell receptor α/δ locus. Enhancer activity was shown to impart long-range, developmentally regulated changes in H3 acetylation, and H3 acetylation status was tightly linked to V(D)J recombination. H3 hyperacetylation is proposed as a molecular mechanism coupling enhancer activity to accessibility for V(D)J recombination.