PT  - JOURNAL ARTICLE
AU  - van der Fits, Leslie
AU  - Memelink, Johan
TI  - ORCA3, a Jasmonate-Responsive Transcriptional Regulator of Plant Primary and Secondary Metabolism
AID  - 10.1126/science.289.5477.295
DP  - 2000 Jul 14
TA  - Science
PG  - 295--297
VI  - 289
IP  - 5477
4099  - http://science.sciencemag.org/content/289/5477/295.short
4100  - http://science.sciencemag.org/content/289/5477/295.full
SO  - Science2000 Jul 14; 289
AB  - Biosynthesis of many classes of secondary metabolites in plants is induced by the stress hormone jasmonate. The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor fromCatharanthus roseus, was isolated by transferred DNA activation tagging. Orca3 overexpression resulted in enhanced expression of several metabolite biosynthetic genes and, consequently, in increased accumulation of terpenoid indole alkaloids. Regulation of metabolite biosynthetic genes by jasmonate-responsive AP2-domain transcription factors may link plant stress responses to changes in metabolism.