RT Journal Article
SR Electronic
T1 Genes Expressed in Human Tumor Endothelium
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1197
OP 1202
DO 10.1126/science.289.5482.1197
VO 289
IS 5482
A1 Croix, Brad St.
A1 Rago, Carlo
A1 Velculescu, Victor
A1 Traverso, Giovanni
A1 Romans, Katharine E.
A1 Montgomery, Elizabeth
A1 Lal, Anita
A1 Riggins, Gregory J.
A1 Lengauer, Christoph
A1 Vogelstein, Bert
A1 Kinzler, Kenneth W.
YR 2000
UL http://science.sciencemag.org/content/289/5482/1197.abstract
AB To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts predominantly expressed in the endothelium, 79 were differentially expressed, including 46 that were specifically elevated in tumor-associated endothelium. Several of these genes encode extracellular matrix proteins, but most are of unknown function. Most of these tumor endothelial markers were expressed in a wide range of tumor types, as well as in normal vessels associated with wound healing and corpus luteum formation. These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies.