RT Journal Article
SR Electronic
T1 Molecular Analysis of <em>FRIGIDA</em>, a Major Determinant of Natural Variation in <em>Arabidopsis</em> Flowering Time
JF Science
JO Science
FD American Association for the Advancement of Science
SP 344
OP 347
DO 10.1126/science.290.5490.344
VO 290
IS 5490
A1 Johanson, Urban
A1 West, Joanne
A1 Lister, Clare
A1 Michaels, Scott
A1 Amasino, Richard
A1 Dean, Caroline
YR 2000
UL http://science.sciencemag.org/content/290/5490/344.abstract
AB Vernalization, the acceleration of flowering by a long period of cold temperature, ensures that many plants overwinter vegetatively and flower in spring. In Arabidopsis, allelic variation at the FRIGIDA (FRI) locus is a major determinant of natural variation in flowering time. Dominant alleles ofFRI confer late flowering, which is reversed to earliness by vernalization. We cloned FRI and analyzed the molecular basis of the allelic variation. Most of the early-flowering ecotypes analyzed carry FRI alleles containing one of two different deletions that disrupt the open reading frame. Loss-of-function mutations at FRI have thus provided the basis for the evolution of many early-flowering ecotypes.