RT Journal Article SR Electronic T1 Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes JF Science JO Science FD American Association for the Advancement of Science SP 2105 OP 2110 DO 10.1126/science.290.5499.2105 VO 290 IS 5499 A1 Riechmann, J. L. A1 Heard, J. A1 Martin, G. A1 Reuber, L. A1 Jiang , C.-Z. A1 Keddie, J. A1 Adam, L. A1 Pineda, O. A1 Ratcliffe, O. J. A1 Samaha, R. R. A1 Creelman, R. A1 Pilgrim, M. A1 Broun, P. A1 Zhang, J. Z. A1 Ghandehari, D. A1 Sherman, B. K. A1 -L. Yu, G. YR 2000 UL http://science.sciencemag.org/content/290/5499/2105.abstract AB The completion of the Arabidopsis thaliana genome sequence allows a comparative analysis of transcriptional regulators across the three eukaryotic kingdoms. Arabidopsis dedicates over 5% of its genome to code for more than 1500 transcription factors, about 45% of which are from families specific to plants.Arabidopsis transcription factors that belong to families common to all eukaryotes do not share significant similarity with those of the other kingdoms beyond the conserved DNA binding domains, many of which have been arranged in combinations specific to each lineage. The genome-wide comparison reveals the evolutionary generation of diversity in the regulation of transcription.