PT  - JOURNAL ARTICLE
AU  - Harmer, Stacey L.
AU  - Hogenesch, John B.
AU  - Straume, Marty
AU  - Chang, Hur-Song
AU  - Han, Bin
AU  - Zhu, Tong
AU  - Wang, Xun
AU  - Kreps, Joel A.
AU  - Kay, Steve A.
TI  - Orchestrated Transcription of Key Pathways in <em>Arabidopsis</em> by the Circadian Clock
AID  - 10.1126/science.290.5499.2110
DP  - 2000 Dec 15
TA  - Science
PG  - 2110--2113
VI  - 290
IP  - 5499
4099  - http://science.sciencemag.org/content/290/5499/2110.short
4100  - http://science.sciencemag.org/content/290/5499/2110.full
SO  - Science2000 Dec 15; 290
AB  - Like most organisms, plants have endogenous biological clocks that coordinate internal events with the external environment. We used high-density oligonucleotide microarrays to examine gene expression in Arabidopsis and found that 6% of the more than 8000 genes on the array exhibited circadian changes in steady-state messenger RNA levels. Clusters of circadian-regulated genes were found in pathways involved in plant responses to light and other key metabolic pathways. Computational analysis of cycling genes allowed the identification of a highly conserved promoter motif that we found to be required for circadian control of gene expression. Our study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote.