RT Journal Article
SR Electronic
T1 Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
JF Science
JO Science
FD American Association for the Advancement of Science
SP 319
OP 322
DO 10.1126/science.291.5502.319
VO 291
IS 5502
A1 Nishimura, Hiroyuki
A1 Okazaki, Taku
A1 Tanaka, Yoshimasa
A1 Nakatani, Kazuki
A1 Hara, Masatake
A1 Matsumori, Akira
A1 Sasayama, Shigetake
A1 Mizoguchi, Akira
A1 Hiai, Hiroshi
A1 Minato, Nagahiro
A1 Honjo, Tasuku
YR 2001
UL http://science.sciencemag.org/content/291/5502/319.abstract
AB Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2−/− mice, caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. All of the affected PD-1−/− mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.