PT  - JOURNAL ARTICLE
AU  - Girardi, Michael
AU  - Oppenheim, David E.
AU  - Steele, Carrie R.
AU  - Lewis, Julia M.
AU  - Glusac, Earl
AU  - Filler, Renata
AU  - Hobby, Paul
AU  - Sutton, Brian
AU  - Tigelaar, Robert E.
AU  - Hayday, Adrian C.
TI  - Regulation of Cutaneous Malignancy by γδ T Cells
AID  - 10.1126/science.1063916
DP  - 2001 Oct 19
TA  - Science
PG  - 605--609
VI  - 294
IP  - 5542
4099  - http://science.sciencemag.org/content/294/5542/605.short
4100  - http://science.sciencemag.org/content/294/5542/605.full
SO  - Science2001 Oct 19; 294
AB  - The localization of γδ T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking γδ cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex–related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ γδ cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.