PT  - JOURNAL ARTICLE
AU  - Anderson, Richard G. W.
AU  - Jacobson, Ken
TI  - A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains
AID  - 10.1126/science.1068886
DP  - 2002 Jun 07
TA  - Science
PG  - 1821--1825
VI  - 296
IP  - 5574
4099  - http://science.sciencemag.org/content/296/5574/1821.short
4100  - http://science.sciencemag.org/content/296/5574/1821.full
SO  - Science2002 Jun 07; 296
AB  - The surface membrane of cells is studded with morphologically distinct regions, or domains, like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a particular function, such as nutrient absorption, cell-cell communication, and endocytosis. Lipid domains, which include caveolae and rafts, are one of the least understood membrane domains. These domains are high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling. A major mystery, however, is how resident molecules are targeted to lipid domains. Here, we propose that the molecular address for proteins targeted to lipid domains is a lipid shell.