PT  - JOURNAL ARTICLE
AU  - Muranyi, Walter
AU  - Haas, Jürgen
AU  - Wagner, Markus
AU  - Krohne, Georg
AU  - Koszinowski, Ulrich H.
TI  - Cytomegalovirus Recruitment of Cellular Kinases to Dissolve the Nuclear Lamina
AID  - 10.1126/science.1071506
DP  - 2002 Aug 02
TA  - Science
PG  - 854--857
VI  - 297
IP  - 5582
4099  - http://science.sciencemag.org/content/297/5582/854.short
4100  - http://science.sciencemag.org/content/297/5582/854.full
SO  - Science2002 Aug 02; 297
AB  - The passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a β-herpesviral protein of murine cytomegalovirus. M50/p35 inserts into the inner nuclear membrane and is aggregated by a second viral protein, M53/p38, to form the capsid docking site. M50/p35 recruits the cellular protein kinase C for phosphorylation and dissolution of the nuclear lamina, suggesting that herpesviruses target a critical element of nuclear architecture.