PT  - JOURNAL ARTICLE
AU  - Sharma, Sonia
AU  - tenOever, Benjamin R.
AU  - Grandvaux, Nathalie
AU  - Zhou, Guo-Ping
AU  - Lin, Rongtuan
AU  - Hiscott, John
TI  - Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
AID  - 10.1126/science.1081315
DP  - 2003 May 16
TA  - Science
PG  - 1148--1151
VI  - 300
IP  - 5622
4099  - http://science.sciencemag.org/content/300/5622/1148.short
4100  - http://science.sciencemag.org/content/300/5622/1148.full
SO  - Science2003 May 16; 300
AB  - Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)–related kinases IKKϵ and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.