PT - JOURNAL ARTICLE AU - Sharma, Sonia AU - tenOever, Benjamin R. AU - Grandvaux, Nathalie AU - Zhou, Guo-Ping AU - Lin, Rongtuan AU - Hiscott, John TI - Triggering the Interferon Antiviral Response Through an IKK-Related Pathway AID - 10.1126/science.1081315 DP - 2003 May 16 TA - Science PG - 1148--1151 VI - 300 IP - 5622 4099 - http://science.sciencemag.org/content/300/5622/1148.short 4100 - http://science.sciencemag.org/content/300/5622/1148.full SO - Science2003 May 16; 300 AB - Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)–related kinases IKKϵ and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.