PT - JOURNAL ARTICLE AU - Alon, U. TI - Biological Networks: The Tinkerer as an Engineer AID - 10.1126/science.1089072 DP - 2003 Sep 26 TA - Science PG - 1866--1867 VI - 301 IP - 5641 4099 - http://science.sciencemag.org/content/301/5641/1866.short 4100 - http://science.sciencemag.org/content/301/5641/1866.full SO - Science2003 Sep 26; 301 AB - This viewpoint comments on recent advances in understanding the design principles of biological networks. It highlights the surprising discovery of “good-engineering” principles in biochemical circuitry that evolved by random tinkering.