PT - JOURNAL ARTICLE AU - Ridley, Anne J. AU - Schwartz, Martin A. AU - Burridge, Keith AU - Firtel, Richard A. AU - Ginsberg, Mark H. AU - Borisy, Gary AU - Parsons, J. Thomas AU - Horwitz, Alan Rick TI - Cell Migration: Integrating Signals from Front to Back AID - 10.1126/science.1092053 DP - 2003 Dec 05 TA - Science PG - 1704--1709 VI - 302 IP - 5651 4099 - http://science.sciencemag.org/content/302/5651/1704.short 4100 - http://science.sciencemag.org/content/302/5651/1704.full SO - Science2003 Dec 05; 302 AB - Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.