PT  - JOURNAL ARTICLE
AU  - Wilson, Rachel I.
AU  - Turner, Glenn C.
AU  - Laurent, Gilles
TI  - Transformation of Olfactory Representations in the <em>Drosophila</em> Antennal Lobe
AID  - 10.1126/science.1090782
DP  - 2004 Jan 16
TA  - Science
PG  - 366--370
VI  - 303
IP  - 5656
4099  - http://science.sciencemag.org/content/303/5656/366.short
4100  - http://science.sciencemag.org/content/303/5656/366.full
SO  - Science2004 Jan 16; 303
AB  - Molecular genetics has revealed a precise stereotypy in the projection of primary olfactory sensory neurons onto secondary neurons. A major challenge is to understand how this mapping translates into odor responses in these second-order neurons. We investigated this question in Drosophila using whole-cell recordings in vivo. We observe that monomolecular odors generally elicit responses in large ensembles of antennal lobe neurons. Comparison of odor-evoked activity from afferents and postsynaptic neurons in the same glomerulus revealed that second-order neurons display broader tuning and more complex responses than their primary afferents. This indicates a major transformation of odor representations, implicating lateral interactions within the antennal lobe.