PT  - JOURNAL ARTICLE
AU  - Dietrich, Fred S.
AU  - Voegeli, Sylvia
AU  - Brachat, Sophie
AU  - Lerch, Anita
AU  - Gates, Krista
AU  - Steiner, Sabine
AU  - Mohr, Christine
AU  - Pöhlmann, Rainer
AU  - Luedi, Philippe
AU  - Choi, Sangdun
AU  - Wing, Rod A.
AU  - Flavier, Albert
AU  - Gaffney, Thomas D.
AU  - Philippsen, Peter
TI  - The <em>Ashbya gossypii</em> Genome as a Tool for Mapping the Ancient <em>Saccharomyces cerevisiae</em> Genome
AID  - 10.1126/science.1095781
DP  - 2004 Apr 09
TA  - Science
PG  - 304--307
VI  - 304
IP  - 5668
4099  - http://science.sciencemag.org/content/304/5668/304.short
4100  - http://science.sciencemag.org/content/304/5668/304.full
SO  - Science2004 Apr 09; 304
AB  - We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication orfusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.