RT Journal Article
SR Electronic
T1 The <em>Ashbya gossypii</em> Genome as a Tool for Mapping the Ancient <em>Saccharomyces cerevisiae</em> Genome
JF Science
JO Science
FD American Association for the Advancement of Science
SP 304
OP 307
DO 10.1126/science.1095781
VO 304
IS 5668
A1 Dietrich, Fred S.
A1 Voegeli, Sylvia
A1 Brachat, Sophie
A1 Lerch, Anita
A1 Gates, Krista
A1 Steiner, Sabine
A1 Mohr, Christine
A1 Pöhlmann, Rainer
A1 Luedi, Philippe
A1 Choi, Sangdun
A1 Wing, Rod A.
A1 Flavier, Albert
A1 Gaffney, Thomas D.
A1 Philippsen, Peter
YR 2004
UL http://science.sciencemag.org/content/304/5668/304.abstract
AB We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication orfusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.