RT Journal Article
SR Electronic
T1 Resolution of Sister Telomere Association Is Required for Progression Through Mitosis
JF Science
JO Science
FD American Association for the Advancement of Science
SP 97
OP 100
DO 10.1126/science.1094754
VO 304
IS 5667
A1 Dynek, Jasmin N.
A1 Smith, Susan
YR 2004
UL http://science.sciencemag.org/content/304/5667/97.abstract
AB Cohesins keep sister chromatids associated from the time of their replication in S phase until the onset of anaphase. In vertebrate cells, two distinct pathways dissociate cohesins, one acts on chromosome arms and the other on centromeres. Here, we describe a third pathway that acts on telomeres. Knockdown of tankyrase 1, a telomeric poly(ADP-ribose) polymerase caused mitotic arrest. Chromosomes aligned normally on the metaphase plate but were unable to segregate. Sister chromatids separated at centromeres and arms but remained associated at telomeres, apparently through proteinaceous bridges. Thus, telomeres may require a unique tankyrase 1–dependent mechanism for sister chromatid resolution before anaphase.