RT Journal Article
SR Electronic
T1 Maintained Cardiac Pumping in Anoxic Crucian Carp
JF Science
JO Science
FD American Association for the Advancement of Science
SP 77
OP 77
DO 10.1126/science.1100763
VO 306
IS 5693
A1 Stecyk, Jonathan A. W.
A1 Stensløkken, Kåre-Olav
A1 Farrell, Anthony P.
A1 Nilsson, Göran E.
YR 2004
UL http://science.sciencemag.org/content/306/5693/77.abstract
AB Like most vertebrates, humans die within minutes when deprived of molecular oxygen (anoxia), in part because of cardiac failure. In contrast, some freshwater turtles can survive anoxia for months at low temperatures, but to do so, they drastically suppress cardiac activity and autonomic cardiovascular control. Although Carassius carassius, the crucian carp, shares this anoxia tolerance, we show that it has a unique ability among vertebrates to retain normal cardiac performance and autonomic cardiovascular regulation for at least 5 days of anoxia. These responses point to an unusual tolerance of a vertebrate heart and autonomic nervous system to prolonged anoxia.