RT Journal Article
SR Electronic
T1 Prospects for Building the Tree of Life from Large Sequence Databases
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1172
OP 1174
DO 10.1126/science.1102036
VO 306
IS 5699
A1 Driskell, Amy C.
A1 Ané, Cécile
A1 Burleigh, J. Gordon
A1 McMahon, Michelle M.
A1 O'Meara, Brian C.
A1 Sanderson, Michael J.
YR 2004
UL http://science.sciencemag.org/content/306/5699/1172.abstract
AB We assess the phylogenetic potential of ∼300,000 protein sequences sampled from Swiss-Prot and GenBank. Although only a small subset of these data was potentially phylogenetically informative, this subset retained a substantial fraction of the original taxonomic diversity. Sampling biases in the databases necessitate building phylogenetic data sets that have large numbers of missing entries. However, an analysis of two “supermatrices” suggests that even data sets with as much as 92% missing data can provide insights into broad sections of the tree of life.