RT Journal Article
SR Electronic
T1 Pesticide Resistance via Transposition-Mediated Adaptive Gene Truncation in <em>Drosophila</em>
JF Science
JO Science
FD American Association for the Advancement of Science
SP 764
OP 767
DO 10.1126/science.1112699
VO 309
IS 5735
A1 Aminetzach, Yael T.
A1 Macpherson, J. Michael
A1 Petrov, Dmitri A.
YR 2005
UL http://science.sciencemag.org/content/309/5735/764.abstract
AB To study adaptation, it is essential to identify multiple adaptive mutations and to characterize their molecular, phenotypic, selective, and ecological consequences. Here we describe a genomic screen for adaptive insertions of transposable elements in Drosophila. Using a pilot application of this screen, we have identified an adaptive transposable element insertion, which truncates a gene and apparently generates a functional protein in the process. The insertion of this transposable element confers increased resistance to an organophosphate pesticide and has spread in D. melanogaster recently.