PT  - JOURNAL ARTICLE
AU  - Koprivica, Vuk
AU  - Cho, Kin-Sang
AU  - Park, Jong Bae
AU  - Yiu, Glenn
AU  - Atwal, Jasvinder
AU  - Gore, Bryan
AU  - Kim, Jieun A.
AU  - Lin, Estelle
AU  - Tessier-Lavigne, Marc
AU  - Chen, Dong Feng
AU  - He, Zhigang
TI  - EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans
AID  - 10.1126/science.1115462
DP  - 2005 Oct 07
TA  - Science
PG  - 106--110
VI  - 310
IP  - 5745
4099  - http://science.sciencemag.org/content/310/5745/106.short
4100  - http://science.sciencemag.org/content/310/5745/106.full
SO  - Science2005 Oct 07; 310
AB  - Inhibitory molecules associated with myelin and the glial scar limit axon regeneration in the adult central nervous system (CNS), but the underlying signaling mechanisms of regeneration inhibition are not fully understood. Here, we show that suppressing the kinase function of the epidermal growth factor receptor (EGFR) blocks the activities of both myelin inhibitors and chondroitin sulfate proteoglycans in inhibiting neurite outgrowth. In addition, regeneration inhibitors trigger the phosphorylation of EGFR in a calcium-dependent manner. Local administration of EGFR inhibitors promotes significant regeneration of injured optic nerve fibers, pointing to a promising therapeutic avenue for enhancing axon regeneration after CNS injury.