RT Journal Article
SR Electronic
T1 A Molecular Framework for Plant Regeneration
JF Science
JO Science
FD American Association for the Advancement of Science
SP 385
OP 388
DO 10.1126/science.1121790
VO 311
IS 5759
A1 Xu, Jian
A1 Hofhuis, Hugo
A1 Heidstra, Renze
A1 Sauer, Michael
A1 Friml, Jiří
A1 Scheres, Ben
YR 2006
UL http://science.sciencemag.org/content/311/5759/385.abstract
AB Plants and some animals have a profound capacity to regenerate organs from adult tissues. Molecular mechanisms for regeneration have, however, been largely unexplored. Here we investigate a local regeneration response in Arabidopsis roots. Laser-induced wounding disrupts the flow of auxin—a cell-fate–instructive plant hormone—in root tips, and we demonstrate that resulting cell-fate changes require the PLETHORA, SHORTROOT, and SCARECROW transcription factors. These transcription factors regulate the expression and polar position of PIN auxin efflux–facilitating membrane proteins to reconstitute auxin transport in renewed root tips.Thus, a regeneration mechanism using embryonic root stem-cell patterning factors first responds to and subsequently stabilizes a new hormone distribution.