RT Journal Article SR Electronic T1 A Molecular Framework for Plant Regeneration JF Science JO Science FD American Association for the Advancement of Science SP 385 OP 388 DO 10.1126/science.1121790 VO 311 IS 5759 A1 Xu, Jian A1 Hofhuis, Hugo A1 Heidstra, Renze A1 Sauer, Michael A1 Friml, Jiří A1 Scheres, Ben YR 2006 UL http://science.sciencemag.org/content/311/5759/385.abstract AB Plants and some animals have a profound capacity to regenerate organs from adult tissues. Molecular mechanisms for regeneration have, however, been largely unexplored. Here we investigate a local regeneration response in Arabidopsis roots. Laser-induced wounding disrupts the flow of auxin—a cell-fate–instructive plant hormone—in root tips, and we demonstrate that resulting cell-fate changes require the PLETHORA, SHORTROOT, and SCARECROW transcription factors. These transcription factors regulate the expression and polar position of PIN auxin efflux–facilitating membrane proteins to reconstitute auxin transport in renewed root tips.Thus, a regeneration mechanism using embryonic root stem-cell patterning factors first responds to and subsequently stabilizes a new hormone distribution.