PT  - JOURNAL ARTICLE
AU  - Domon, Bruno
AU  - Aebersold, Ruedi
TI  - Mass Spectrometry and Protein Analysis
AID  - 10.1126/science.1124619
DP  - 2006 Apr 14
TA  - Science
PG  - 212--217
VI  - 312
IP  - 5771
4099  - http://science.sciencemag.org/content/312/5771/212.short
4100  - http://science.sciencemag.org/content/312/5771/212.full
SO  - Science2006 Apr 14; 312
AB  - Mass spectrometry is a central analytical technique for protein research and for the study of biomolecules in general. Driven by the need to identify, characterize, and quantify proteins at ever increasing sensitivity and in ever more complex samples, a wide range of new mass spectrometry–based analytical platforms and experimental strategies have emerged. Here we review recent advances in mass spectrometry instrumentation in the context of current and emerging research strategies in protein science.