RT Journal Article SR Electronic T1 Waking Experience Affects Sleep Need in Drosophila JF Science JO Science FD American Association for the Advancement of Science SP 1775 OP 1781 DO 10.1126/science.1130408 VO 313 IS 5794 A1 Ganguly-Fitzgerald, Indrani A1 Donlea, Jeff A1 Shaw, Paul J. YR 2006 UL http://science.sciencemag.org/content/313/5794/1775.abstract AB Sleep is a vital, evolutionarily conserved phenomenon, whose function is unclear. Although mounting evidence supports a role for sleep in the consolidation of memories, until now, a molecular connection between sleep, plasticity, and memory formation has been difficult to demonstrate. We establish Drosophila as a model to investigate this relation and demonstrate that the intensity and/or complexity of prior social experience stably modifies sleep need and architecture. Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3′,5′-monophosphate signaling pathways and a particular subset of 17 long-term memory genes.