RT Journal Article
SR Electronic
T1 Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1262
OP 1266
DO 10.1126/science.1137450
VO 315
IS 5816
A1 Lamsa, Karri P.
A1 Heeroma, Joost H.
A1 Somogyi, Peter
A1 Rusakov, Dmitri A.
A1 Kullmann, Dimitri M.
YR 2007
UL http://science.sciencemag.org/content/315/5816/1262.abstract
AB Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is “anti-Hebbian”:Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.