RT Journal Article SR Electronic T1 Anti-Hebbian Long-Term Potentiation in the Hippocampal Feedback Inhibitory Circuit JF Science JO Science FD American Association for the Advancement of Science SP 1262 OP 1266 DO 10.1126/science.1137450 VO 315 IS 5816 A1 Lamsa, Karri P. A1 Heeroma, Joost H. A1 Somogyi, Peter A1 Rusakov, Dmitri A. A1 Kullmann, Dimitri M. YR 2007 UL http://science.sciencemag.org/content/315/5816/1262.abstract AB Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is “anti-Hebbian”:Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.