RT Journal Article SR Electronic T1 High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression JF Science JO Science FD American Association for the Advancement of Science SP 819 OP 823 DO 10.1126/science.1144400 VO 317 IS 5839 A1 Airan, Raag D. A1 Meltzer, Leslie A. A1 Roy, Madhuri A1 Gong, Yuqing A1 Chen, Han A1 Deisseroth, Karl YR 2007 UL http://science.sciencemag.org/content/317/5839/819.abstract AB The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices after bidirectional modulation of affective state in rat models of depression. We found that a simple measure of real-time activity—stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield—accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms.