RT Journal Article
SR Electronic
T1 High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression
JF Science
JO Science
FD American Association for the Advancement of Science
SP 819
OP 823
DO 10.1126/science.1144400
VO 317
IS 5839
A1 Airan, Raag D.
A1 Meltzer, Leslie A.
A1 Roy, Madhuri
A1 Gong, Yuqing
A1 Chen, Han
A1 Deisseroth, Karl
YR 2007
UL http://science.sciencemag.org/content/317/5839/819.abstract
AB The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices after bidirectional modulation of affective state in rat models of depression. We found that a simple measure of real-time activity—stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield—accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms.