RT Journal Article
SR Electronic
T1 Leptin Regulates Striatal Regions and Human Eating Behavior
JF Science
JO Science
FD American Association for the Advancement of Science
SP 1355
OP 1355
DO 10.1126/science.1144599
VO 317
IS 5843
A1 Farooqi, I. Sadaf
A1 Bullmore, Edward
A1 Keogh, Julia
A1 Gillard, Jonathan
A1 O'Rahilly, Stephen
A1 Fletcher, Paul C.
YR 2007
UL http://science.sciencemag.org/content/317/5843/1355.abstract
AB Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. We used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and after 7 days of leptin replacement therapy. Leptin was found to modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption.