PT  - JOURNAL ARTICLE
AU  - Prahlad, Veena
AU  - Cornelius, Tyler
AU  - Morimoto, Richard I.
TI  - Regulation of the Cellular Heat Shock Response in <em>Caenorhabditis elegans</em> by Thermosensory Neurons
AID  - 10.1126/science.1156093
DP  - 2008 May 09
TA  - Science
PG  - 811--814
VI  - 320
IP  - 5877
4099  - http://science.sciencemag.org/content/320/5877/811.short
4100  - http://science.sciencemag.org/content/320/5877/811.full
SO  - Science2008 May 09; 320
AB  - Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.