RT Journal Article
SR Electronic
T1 Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
JF Science
JO Science
FD American Association for the Advancement of Science
SP 197
OP 201
DO 10.1126/science.1176225
VO 325
IS 5937
A1 Garten, Rebecca J.
A1 Davis, C. Todd
A1 Russell, Colin A.
A1 Shu, Bo
A1 Lindstrom, Stephen
A1 Balish, Amanda
A1 Sessions, Wendy M.
A1 Xu, Xiyan
A1 Skepner, Eugene
A1 Deyde, Varough
A1 Okomo-Adhiambo, Margaret
A1 Gubareva, Larisa
A1 Barnes, John
A1 Smith, Catherine B.
A1 Emery, Shannon L.
A1 Hillman, Michael J.
A1 Rivailler, Pierre
A1 Smagala, James
A1 de Graaf, Miranda
A1 Burke, David F.
A1 Fouchier, Ron A. M.
A1 Pappas, Claudia
A1 Alpuche-Aranda, Celia M.
A1 López-Gatell, Hugo
A1 Olivera, Hiram
A1 López, Irma
A1 Myers, Christopher A.
A1 Faix, Dennis
A1 Blair, Patrick J.
A1 Yu, Cindy
A1 Keene, Kimberly M.
A1 Dotson, P. David
A1 Boxrud, David
A1 Sambol, Anthony R.
A1 Abid, Syed H.
A1 St. George, Kirsten
A1 Bannerman, Tammy
A1 Moore, Amanda L.
A1 Stringer, David J.
A1 Blevins, Patricia
A1 Demmler-Harrison, Gail J.
A1 Ginsberg, Michele
A1 Kriner, Paula
A1 Waterman, Steve
A1 Smole, Sandra
A1 Guevara, Hugo F.
A1 Belongia, Edward A.
A1 Clark, Patricia A.
A1 Beatrice, Sara T.
A1 Donis, Ruben
A1 Katz, Jacqueline
A1 Finelli, Lyn
A1 Bridges, Carolyn B.
A1 Shaw, Michael
A1 Jernigan, Daniel B.
A1 Uyeki, Timothy M.
A1 Smith, Derek J.
A1 Klimov, Alexander I.
A1 Cox, Nancy J.
YR 2009
UL http://science.sciencemag.org/content/325/5937/197.abstract
AB Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).