PT  - JOURNAL ARTICLE
AU  - Rosen, Jeffrey M.
AU  - Jordan, Craig T.
TI  - The Increasing Complexity of the Cancer Stem Cell Paradigm
AID  - 10.1126/science.1171837
DP  - 2009 Jun 26
TA  - Science
PG  - 1670--1673
VI  - 324
IP  - 5935
4099  - http://science.sciencemag.org/content/324/5935/1670.short
4100  - http://science.sciencemag.org/content/324/5935/1670.full
SO  - Science2009 Jun 26; 324
AB  - The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past 5 to 10 years but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of the debate, the parameters by which CSCs can or cannot be defined, and the identification of new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.