PT  - JOURNAL ARTICLE
AU  - Rehwinkel, Jan
AU  - Reis e Sousa, Caetano
TI  - RIGorous Detection: Exposing Virus Through RNA Sensing
AID  - 10.1126/science.1185068
DP  - 2010 Jan 15
TA  - Science
PG  - 284--286
VI  - 327
IP  - 5963
4099  - http://science.sciencemag.org/content/327/5963/284.short
4100  - http://science.sciencemag.org/content/327/5963/284.full
SO  - Science2010 Jan 15; 327
AB  - Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.