RT Journal Article
SR Electronic
T1 RIGorous Detection: Exposing Virus Through RNA Sensing
JF Science
JO Science
FD American Association for the Advancement of Science
SP 284
OP 286
DO 10.1126/science.1185068
VO 327
IS 5963
A1 Rehwinkel, Jan
A1 Reis e Sousa, Caetano
YR 2010
UL http://science.sciencemag.org/content/327/5963/284.abstract
AB Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.