RT Journal Article
SR Electronic
T1 Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network
JF Science
JO Science
FD American Association for the Advancement of Science
SP 596
OP 601
DO 10.1126/science.1203659
VO 333
IS 6042
A1 Mukhtar, M. Shahid
A1 Carvunis, Anne-Ruxandra
A1 Dreze, Matija
A1 Epple, Petra
A1 Steinbrenner, Jens
A1 Moore, Jonathan
A1 Tasan, Murat
A1 Galli, Mary
A1 Hao, Tong
A1 Nishimura, Marc T.
A1 Pevzner, Samuel J.
A1 Donovan, Susan E.
A1 Ghamsari, Lila
A1 Santhanam, Balaji
A1 Romero, Viviana
A1 Poulin, Matthew M.
A1 Gebreab, Fana
A1 Gutierrez, Bryan J.
A1 Tam, Stanley
A1 Monachello, Dario
A1 Boxem, Mike
A1 Harbort, Christopher J.
A1 McDonald, Nathan
A1 Gai, Lantian
A1 Chen, Huaming
A1 He, Yijian
A1 ,
A1 Vandenhaute, Jean
A1 Roth, Frederick P.
A1 Hill, David E.
A1 Ecker, Joseph R.
A1 Vidal, Marc
A1 Beynon, Jim
A1 Braun, Pascal
A1 Dangl, Jeffery L.
YR 2011
UL http://science.sciencemag.org/content/333/6042/596.abstract
AB Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.