PT  - JOURNAL ARTICLE
AU  - Shin, Seung Chul
AU  - Kim, Sung-Hee
AU  - You, Hyejin
AU  - Kim, Boram
AU  - Kim, Aeri C.
AU  - Lee, Kyung-Ah
AU  - Yoon, Joo-Heon
AU  - Ryu, Ji-Hwan
AU  - Lee, Won-Jae
TI  - <em>Drosophila</em> Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling
AID  - 10.1126/science.1212782
DP  - 2011 Nov 04
TA  - Science
PG  - 670--674
VI  - 334
IP  - 6056
4099  - http://science.sciencemag.org/content/334/6056/670.short
4100  - http://science.sciencemag.org/content/334/6056/670.full
SO  - Science2011 Nov 04; 334
AB  - The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone–dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH.