RT Journal Article
SR Electronic
T1 Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
JF Science
JO Science
FD American Association for the Advancement of Science
SP 565
OP 569
DO 10.1126/science.aad3369
VO 352
IS 6285
A1 Zhernakova, Alexandra
A1 Kurilshikov, Alexander
A1 Bonder, Marc Jan
A1 Tigchelaar, Ettje F.
A1 Schirmer, Melanie
A1 Vatanen, Tommi
A1 Mujagic, Zlatan
A1 Vila, Arnau Vich
A1 Falony, Gwen
A1 Vieira-Silva, Sara
A1 Wang, Jun
A1 Imhann, Floris
A1 Brandsma, Eelke
A1 Jankipersadsing, Soesma A.
A1 Joossens, Marie
A1 Cenit, Maria Carmen
A1 Deelen, Patrick
A1 Swertz, Morris A.
A1 ,
A1 Weersma, Rinse K.
A1 Feskens, Edith J. M.
A1 Netea, Mihai G.
A1 Gevers, Dirk
A1 Jonkers, Daisy
A1 Franke, Lude
A1 Aulchenko, Yurii S.
A1 Huttenhower, Curtis
A1 Raes, Jeroen
A1 Hofker, Marten H.
A1 Xavier, Ramnik J.
A1 Wijmenga, Cisca
A1 Fu, Jingyuan
YR 2016
UL http://science.sciencemag.org/content/352/6285/565.abstract
AB For the benefit of future clinical studies, it is critical to establish what constitutes a “normal” gut microbiome, if it exists at all. Through fecal samples and questionnaires, Falony et al. and Zhernakova et al. targeted general populations in Belgium and the Netherlands, respectively. Gut microbiota composition correlated with a range of factors including diet, use of medication, red blood cell counts, fecal chromogranin A, and stool consistency. The data give some hints for possible biomarkers of normal gut communities.Science, this issue pp. 560 and 565Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.