PT  - JOURNAL ARTICLE
AU  - Wolin, Sandra L.
AU  - Maquat, Lynne E.
TI  - Cellular RNA surveillance in health and disease
AID  - 10.1126/science.aax2957
DP  - 2019 Nov 15
TA  - Science
PG  - 822--827
VI  - 366
IP  - 6467
4099  - http://science.sciencemag.org/content/366/6467/822.short
4100  - http://science.sciencemag.org/content/366/6467/822.full
SO  - Science2019 Nov 15; 366
AB  - The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one or more proteins and eliminating mRNAs that encode abnormal, potentially toxic proteins. Mutations in components of diverse RNA surveillance pathways manifest as disease. Some mutations are characterized by increased interferon production, suggesting that a major role of these pathways is to prevent aberrant cellular RNAs from being recognized as “non-self.” Other mutations are common in cancer, or result in developmental defects, revealing the importance of RNA surveillance to cell and organismal function.